Fujiwara Y, Hamada M, Shigematsu Y, Sumimoto T, Hamamoto K, Hiwada K
2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
J Cardiovasc Pharmacol. 1991;17 Suppl 2:S148-50. doi: 10.1097/00005344-199117002-00036.
To assess the regional cardiac adrenergic innervation in patients with essential hypertension (EHT), simultaneous iodine-123 metaiodobenzylguanidine ([123I]MIBG) and thallium-201 (201Tl) myocardial imagings were performed in five patients with EHT, seven patients with hypertrophic cardiomyopathy (HCM), and seven normal subjects. Short axial images at rest were divided into five segments: anterior, septal, posterior, lateral, and apical segments. Percent regional uptake (%RU) of 201Tl except the septal segment in patients with EHT showed no significant difference. However, the %RU of [123I]MIBG at posterior, lateral, and apical segments was significantly lower than that at anterior and septal segments in EHT. This intraimage heterogeneity of [123I]MIBG was also observed in HCM. These results suggest that there is a difference in regional adrenergic innervation of the left ventricle with myocardial hypertrophy.
为评估原发性高血压（EHT）患者的局部心脏肾上腺素能神经支配情况，对5例EHT患者、7例肥厚型心肌病（HCM）患者和7名正常受试者同时进行了碘-123间碘苄胍（[123I]MIBG）和铊-201（201Tl）心肌显像。静息状态下的短轴图像被分为五个节段：前壁、间隔、后壁、侧壁和心尖节段。EHT患者中，除间隔节段外，201Tl的局部摄取百分比（%RU）无显著差异。然而，EHT患者后壁、侧壁和心尖节段的[123I]MIBG的%RU显著低于前壁和间隔节段。在HCM患者中也观察到了[123I]MIBG的这种图像内异质性。这些结果表明，心肌肥厚患者左心室的局部肾上腺素能神经支配存在差异。
