Taki J, Nakajima K, Bunko H, Simizu M, Muramori A, Hisada K
Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan.
Eur J Nucl Med. 1990;17(5):264-8. doi: 10.1007/BF00812368.
Whole-body distribution of iodine 123 metaiodobenzylguanidine (123I-mIBG) was evaluated in 27 patients with hypertrophic cardiomyopathy (HCM). At 1 and 4 h after injection, anterior and posterior whole-body images were obtained with a dual-headed, camera-computer system. Patients were classified into three groups based on the septal wall thickness as determined by echocardiography: group 1 consisted of 7 patients with less than or equal to 15 mm septal thickness, group 2 included 12 patients with 16-19 mm septal thickness, and group 3 included 6 patients with greater than or equal to 20 mm septal thickness. Although the myocardial mIBG uptakes at 1 h were similar among these groups (1.84% +/- 0.19%, 1.95% +/- 0.38%, 1.98% +/- 0.57%, respectively; NS), mIBG washout from the heart in group 3 was faster than in groups 1 and 2 (31.5% +/- 13.0% vs. 15.8% +/- 11.0% (group 1, P less than 0.05), 17.6% +/- 7.3% (group 2, P less than 0.01)). There was a significant positive correlation between mIBG washout from the heart and septal thickness, with correlation coefficient r = 0.52 (P less than 0.01). The liver, lung, parotid gland, spleen and skeletal muscle showed similar mIBG uptake and washout among the three groups. We conclude from these data that mIBG washout from the heart in HCM was faster in patients with severe hypertrophy than in patients with mild to moderate hypertrophy, and hence it may be a useful parameter for evaluating the severity of altered adrenergic innervation and activities.
对27例肥厚型心肌病（HCM）患者进行了碘123间碘苄胍（123I-mIBG）的全身分布评估。注射后1小时和4小时，使用双头相机-计算机系统获取前后位全身图像。根据超声心动图测定的室间隔厚度将患者分为三组：第1组包括7例室间隔厚度小于或等于15mm的患者，第2组包括12例室间隔厚度为16-19mm的患者，第3组包括6例室间隔厚度大于或等于20mm的患者。尽管这些组在1小时时心肌mIBG摄取相似（分别为1.84%±0.19%、1.95%±0.38%、1.98%±0.57%；无显著性差异），但第3组心脏的mIBG洗脱速度比第1组和第2组快（31.5%±13.0%对15.8%±11.0%（第1组，P<0.05），17.6%±7.3%（第2组，P<0.01））。心脏mIBG洗脱与室间隔厚度之间存在显著正相关，相关系数r = 0.52（P<0.01）。三组中肝脏、肺、腮腺、脾脏和骨骼肌的mIBG摄取和洗脱相似。从这些数据我们得出结论，严重肥厚的HCM患者心脏的mIBG洗脱速度比轻度至中度肥厚患者快，因此它可能是评估肾上腺素能神经支配和活动改变严重程度的一个有用参数。
