Lawson P A, Gharbia S E, Shah H N, Clark D R, Collins M D
Department of Oral Microbiology, London Hospital Medical College, United Kingdom.
Int J Syst Bacteriol. 1991 Jul;41(3):347-54. doi: 10.1099/00207713-41-3-347.
The phylogenetic interrelationships of 14 members of the genus Fusobacterium were investigated by performing a comparative analysis of the 16S rRNA sequences of these organisms. The sequence data revealed considerable intrageneric heterogeneity. The four species Fusobacterium nucleatum (including F. nucleatum subsp. nucleatum, F. nucleatum subsp. polymorphum, "F. nucleatum subsp. fusiforme," and "F. nucleatum subsp. animalis"), Fusobacterium alocis, Fusobacterium periodonticum, and Fusobacterium simiae, which colonize oral cavities, exhibited high levels of sequence homology with each other and formed a distinct group within the genus. Fusobacterium mortiferum, Fusobacterium varium, and Fusobacterium ulcerans also formed a phylogenetically coherent group, as did the two species Fusobacterium gonidiaformans and Fusobacterium necrophorum. Fusobacterium russii and Fusobacterium necrogenes displayed no specific relationship with any of the other fusobacteria. The sequence data are discussed in the context of previous physiological and chemical findings.
通过对14种梭杆菌属成员的16S rRNA序列进行比较分析，研究了它们之间的系统发育关系。序列数据显示出相当大的属内异质性。定殖于口腔的具核梭杆菌（包括具核梭杆菌具核亚种、具核梭杆菌多形亚种、“具核梭杆菌梭形亚种”和“具核梭杆菌动物亚种”）、龈沟梭杆菌、牙周梭杆菌和猕猴梭杆菌这四个种，彼此间表现出高度的序列同源性，并在该属内形成了一个独特的类群。死亡梭杆菌、多变梭杆菌和溃疡梭杆菌也形成了一个系统发育上连贯的类群，产子梭杆菌和坏死梭杆菌这两个种也是如此。拉氏梭杆菌和生坏死梭杆菌与其他任何梭杆菌均无特定关系。结合先前的生理和化学研究结果对序列数据进行了讨论。
