Lansky Ephraim P, Newman Robert A
Punisyn Pharmaceuticals Ltd, Haifa, Israel.
J Ethnopharmacol. 2007 Jan 19;109(2):177-206. doi: 10.1016/j.jep.2006.09.006. Epub 2006 Sep 10.
The last 7 years have seen over seven times as many publications indexed by Medline dealing with pomegranate and Punica granatum than in all the years preceding them. Because of this, and the virtual explosion of interest in pomegranate as a medicinal and nutritional product that has followed, this review is accordingly launched. The pomegranate tree, Punica granatum, especially its fruit, possesses a vast ethnomedical history and represents a phytochemical reservoir of heuristic medicinal value. The tree/fruit can be divided into several anatomical compartments: (1) seed, (2) juice, (3) peel, (4) leaf, (5) flower, (6) bark, and (7) roots, each of which has interesting pharmacologic activity. Juice and peels, for example, possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic and heuristically of interest for the treatment of menopausal symptoms and sequellae. The use of juice, peel and oil have also been shown to possess anticancer activities, including interference with tumor cell proliferation, cell cycle, invasion and angiogenesis. These may be associated with plant based anti-inflammatory effects, The phytochemistry and pharmacological actions of all Punica granatum components suggest a wide range of clinical applications for the treatment and prevention of cancer, as well as other diseases where chronic inflammation is believed to play an essential etiologic role.
在过去7年里，被Medline索引的关于石榴和安石榴的出版物数量是此前所有年份的7倍多。正因如此，以及随之而来的对石榴作为药用和营养产品的兴趣激增，才有了本综述。石榴树，即安石榴，尤其是其果实，拥有悠久的民族医学历史，是一个具有启发性药用价值的植物化学宝库。该树/果实可分为几个解剖部分：（1）种子，（2）果汁，（3）果皮，（4）叶子，（5）花朵，（6）树皮，以及（7）树根，每个部分都具有有趣的药理活性。例如，果汁和果皮具有强大的抗氧化特性，而果汁、果皮和油都具有微弱的雌激素活性，在治疗更年期症状及后遗症方面具有启发性意义。果汁、果皮和油的使用还被证明具有抗癌活性，包括干扰肿瘤细胞增殖、细胞周期、侵袭和血管生成。这些可能与植物性抗炎作用有关。安石榴所有成分的植物化学和药理作用表明，其在治疗和预防癌症以及其他认为慢性炎症起重要病因作用的疾病方面具有广泛的临床应用。
