Musso Carlos G, Núñez Juan F Macías
Int Urol Nephrol. 2006;38(3-4):785-6. doi: 10.1007/s11255-005-0060-4. Epub 2006 Dec 11.
Geriatrics has described three entities: confusional syndrome, incontinente and gait disorders, calling them geriatric giants. Aging process also induces changes in renal physiology such as glomerular filtration rate reduction, and alteration in water and electrolytes handling. These ageing renal changes have been named as nephrogeriatric giants. These two groups of giants, geriatric and nephrogeriatric, can predispose and potentiate each other leading old people to fatal outcomes. These phenomenon of feed-back between these geriatric syndromes has its roots in the loss of complexity that the ageing process has. Complexity means that all the body systems work harmoniously. The process of senescence weakens this coordination among systems undermining complexity and making the old person frail.
意识错乱综合征、大小便失禁和步态障碍,称它们为老年巨症。衰老过程还会引起肾脏生理变化,如肾小球滤过率降低,以及水和电解质处理能力的改变。这些肾脏衰老变化被称为肾脏老年巨症。老年巨症和肾脏老年巨症这两组情况会相互诱发并相互增强,导致老年人出现致命后果。这些老年综合征之间的反馈现象源于衰老过程中复杂性的丧失。复杂性意味着身体所有系统都能和谐运作。衰老过程削弱了各系统之间的这种协调,破坏了复杂性,使老年人变得虚弱。