Gorczynski Reginald M, Terzioglu Ender
Toronto Hospital, University Health Network, Toronto, ON, Canada.
Int Urol Nephrol. 2008;40(4):1117-25. doi: 10.1007/s11255-008-9412-1. Epub 2008 Aug 6.
Aging is associated with many physiological changes in a variety of organ systems. Nevertheless, considerable interest has centred on the possibility that age-related immunological changes may play a key "master" role in regulating many, if not all, subsequent events. A growing body of data, some of it highlighted in this review, supports the notion that host resistance in general is changed in both a qualitative and quantitative manner with age, though the biochemical mechanism(s) underlying such changes are not unique to the immune system per se. Moreover, interventions designed to explore treatments which may reverse some or all of those age-related changes have pointed out a fundamentally important role for nutrition, and the way(s) in which this impacts on host resistance mechanism(s), as having a hitherto unappreciated importance in immunosenescence in general.
衰老与多种器官系统中的许多生理变化相关。然而，相当多的关注集中在这样一种可能性上，即与年龄相关的免疫变化可能在调节许多（如果不是全部）后续事件中发挥关键的“主导”作用。越来越多的数据（本综述中突出了其中一些数据）支持这样一种观点，即总体而言，宿主抵抗力会随着年龄的增长在质量和数量上发生变化，尽管这些变化背后的生化机制并非免疫系统本身所独有。此外，旨在探索可能逆转部分或全部这些与年龄相关变化的治疗方法的干预措施指出，营养及其影响宿主抵抗机制的方式在一般免疫衰老中具有迄今未被认识到的重要性，发挥着根本性的重要作用。
