健康高龄老人中肌酐、尿素、尿酸、水和电解质的肾脏处理
Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old.
作者信息
Musso Carlos Guido, Alvarez Gregori Joaquín, Jauregui José Ricardo, Macías Núñez Juan Florencio
机构信息
Carlos Guido Musso, José Ricardo Jauregui, Ageing Biology Unit, Hospital Italiano of Buenos Aires, Gascón 450, Argentina.
出版信息
World J Nephrol. 2012 Oct 6;1(5):123-6. doi: 10.5527/wjn.v1.i5.123.
Abstract
RENAL PHYSIOLOGY IN THE HEALTHY OLDEST OLD HAS THE FOLLOWING CHARACTERISTICS, IN COMPARISON WITH THE RENAL PHYSIOLOGY IN THE YOUNG: a reduced creatinine clearance, tubular pattern of creatinine back-filtration, preserved proximal tubule sodium reabsorption and uric acid secretion, reduced sodium reabsorption in the thick ascending loop of Henle, reduced free water clearance, increased urea excretion, presence of medulla hypotonicity, reduced urinary dilution and concentration capabilities, and finally a reduced collecting tubules response to furosemide which expresses a reduced potassium excretion in this segment due to a sort of aldosterone resistance. All physiological changes of the aged kidney are the same in both genders.
摘要
与年轻人的肾脏生理学相比，健康的高龄老人的肾脏生理学具有以下特征：肌酐清除率降低、肌酐反向滤过呈肾小管模式、近端小管钠重吸收和尿酸分泌保持正常、髓袢升支粗段钠重吸收减少、自由水清除率降低、尿素排泄增加、髓质低渗、尿液稀释和浓缩能力降低，最后集合小管对呋塞米的反应降低，这表明由于某种醛固酮抵抗，该段钾排泄减少。老年肾脏的所有生理变化在两性中都是相同的。
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本文引用的文献
1
Aging and physiological changes of the kidneys including changes in glomerular filtration rate.肾脏的衰老和生理变化包括肾小球滤过率的变化。
Nephron Physiol. 2011;119 Suppl 1:p1-5. doi: 10.1159/000328010. Epub 2011 Aug 10.
2
Dysfunction of the thick loop of Henle and senescence: from molecular biology to clinical geriatrics.厚壁升支袢功能障碍与衰老：从分子生物学到临床老年医学。
Int Urol Nephrol. 2011 Mar;43(1):249-52. doi: 10.1007/s11255-010-9783-y. Epub 2010 Nov 12.
3
Renal reserve in the oldest old.老年人的肾脏储备功能。
Int Urol Nephrol. 2011 Mar;43(1):253-6. doi: 10.1007/s11255-010-9769-9. Epub 2010 Jul 1.
4
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Int Urol Nephrol. 2010 Mar;42(1):273-7. doi: 10.1007/s11255-009-9547-8. Epub 2009 Mar 10.
5
Creatinine reabsorption by the aged kidney.老年肾脏对肌酐的重吸收
Int Urol Nephrol. 2009;41(3):727-31. doi: 10.1007/s11255-008-9508-7. Epub 2008 Dec 30.
6
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7
Feed-back between geriatric syndromes: general system theory in geriatrics.老年综合征之间的反馈：老年医学中的一般系统理论
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8
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Pediatr Res. 1998 Nov;44(5):639-41. doi: 10.1203/00006450-199811000-00004.
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