儿童期起病精神分裂症中海马体发育的动态图谱。
Dynamic mapping of hippocampal development in childhood onset schizophrenia.
作者信息
Nugent Tom F, Herman David H, Ordonez Anna, Greenstein Deanna, Hayashi Kiralee M, Lenane Marge, Clasen Liv, Jung David, Toga Arthur W, Giedd Jay N, Rapoport Judith L, Thompson Paul M, Gogtay Nitin
机构信息
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA.
出版信息
Schizophr Res. 2007 Feb;90(1-3):62-70. doi: 10.1016/j.schres.2006.10.014. Epub 2006 Dec 11.
Prior cross-sectional anatomic brain imaging studies of the hippocampus in schizophrenia have generally shown loss in total hippocampal volume although the progressive course of these changes remains unknown. We report the first prospective sub-regional maps of hippocampal development in childhood onset schizophrenia (COS), reconstructed from serial brain MRI scans of 29 children with COS scanned every 2 years (87 scans) and compared to 31 controls matched for age, sex, and scan interval (94 scans). As expected, the COS subjects showed significant bilateral deficits (9-10%) in total hippocampal volume which remained consistent between age 9 and 26. However sub-regional maps showed heterogeneous changes with loss of hippocampal volume in both anterior as well as posterior ends while the body of the hippocampus gained in volume suggesting that hippocampal subunits are differentially affected in schizophrenia.
先前对精神分裂症患者海马体进行的横断面解剖学脑成像研究通常显示，海马体总体积减小，尽管这些变化的进展过程尚不清楚。我们报告了儿童期起病精神分裂症（COS）患者海马体发育的首张前瞻性亚区域图谱，该图谱由29例COS儿童每2年进行一次的系列脑部磁共振成像（MRI）扫描重建而成（共87次扫描），并与31名年龄、性别和扫描间隔相匹配的对照儿童（共94次扫描）进行比较。不出所料，COS受试者双侧海马体总体积显著减少（9 - 10%），在9岁至26岁之间保持一致。然而，亚区域图谱显示出异质性变化，海马体前端和后端体积均减小，而海马体主体体积增加，这表明精神分裂症中海马体亚单位受到的影响存在差异。
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