Yoshinari Satoshi, Hamano Shin-Ichiro, Minamitani Motoyuki, Tanaka Manabu, Eto Yoshikatsu
Division of Neurology, Saitama Children's Medical Center, Saitama-city, Saitama, Japan.
Pediatr Neurol. 2007 Jan;36(1):13-6. doi: 10.1016/j.pediatrneurol.2006.09.002.
Isolated cases of human herpesvirus 6 encephalopathy have recently been reported, although the pathophysiology remains largely unknown. To elucidate the changes specific to human herpesvirus 6 encephalopathy on diagnostic images, this study investigated magnetic resonance imaging findings in 10 patients with a diagnosis of human herpesvirus 6 encephalopathy including diffusion-weighted imaging in 6 of 10, and findings of cerebral blood flow imaging by single-photon emission computed tomography in 9 of 10 patients. No abnormalities were evident on T(1)-weighted, T(2)-weighted, or fluid-attenuated inversion-recovery magnetic resonance imaging during acute phases; however, diffusion-weighted imaging indicated abnormal hyperintensity in the subcortical white matter of the frontal lobes in all six patients during the acute phase. Cerebral blood flow single-photon emission computed tomography revealed decreased perfusion, predominantly in the frontal region of all nine patients during their clinical course. Disturbances predominantly affecting the frontal lobes (region) on magnetic resonance imaging and cerebral blood flow single-photon emission computed tomography were common in all patients, suggesting that the findings may be characteristic of human herpesvirus 6 encephalopathy.
近期已有人类疱疹病毒6型脑病的散发病例报道，但其病理生理学仍大多未知。为阐明人类疱疹病毒6型脑病在诊断影像上的特异性变化，本研究调查了10例诊断为人类疱疹病毒6型脑病患者的磁共振成像结果，其中10例中有6例进行了弥散加权成像，10例中有9例进行了单光子发射计算机断层扫描的脑血流成像检查。急性期T1加权、T2加权或液体衰减反转恢复磁共振成像均未发现明显异常；然而，弥散加权成像显示，所有6例患者在急性期额叶皮质下白质均出现异常高信号。脑血流单光子发射计算机断层扫描显示，所有9例患者在病程中灌注均降低，主要累及额叶区域。磁共振成像和脑血流单光子发射计算机断层扫描显示主要累及额叶（区域）的病变在所有患者中均很常见，提示这些表现可能是人类疱疹病毒6型脑病的特征。
