Herrera José, Chávez Maribel, Marín Crispín
Renal Service and the Department of Internal Medicine, Universidad del Zulia School of Medicine, Maracaibo, Venezuela.
Ren Fail. 2006;28(8):749-51. doi: 10.1080/08860220600925651.
A young female with essential hypertension developed progressive azotemia; renal biopsy showed hypertensive nephrosclerosis with considerable tubulointerstitial disease and cellular infiltration. The addition of mycophenolate mofetil (MMF) to her antihypertensive treatment resulted in a dramatic improvement of renal function during the following three months. When the patient discontinued MMF treatment, end-stage renal failure rapidly developed. This patient represents the first report of the beneficial use of MMF in non-immune chronic renal disease and demonstrates that significant functional improvement may be obtained with the addition of MMF to the treatment of hypertensive nephrosclerosis for patients in whom there is significant tubulointerstitial inflammatory infiltration.
一名患有原发性高血压的年轻女性出现了进行性氮质血症；肾活检显示为高血压性肾硬化，伴有相当程度的肾小管间质疾病和细胞浸润。在她的抗高血压治疗中加用霉酚酸酯（MMF）后，在接下来的三个月里肾功能显著改善。当患者停用MMF治疗后，终末期肾衰竭迅速发展。该患者是MMF在非免疫性慢性肾病中有益应用的首例报告，表明对于存在显著肾小管间质炎性浸润的高血压性肾硬化患者，在治疗中加用MMF可获得显著的功能改善。
