Ataide Sandro F, Ibba Michael
Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
ACS Chem Biol. 2006 Jun 20;1(5):285-97. doi: 10.1021/cb600200k.
The aminoacyl-tRNA synthetases (aaRSs) are responsible for selecting specific amino acids for protein synthesis, and this essential role in translation has garnered them much attention as targets for novel antimicrobials. Understanding how the aaRSs evolved efficient substrate selection offers a potential route to develop useful inhibitors of microbial protein synthesis. Here, we discuss discrimination of small molecules by aaRSs, and how the evolutionary divergence of these mechanisms offers a means to target inhibitors against these essential microbial enzymes.
氨酰-tRNA合成酶（aaRSs）负责为蛋白质合成选择特定的氨基酸，并且这种在翻译过程中的关键作用使它们作为新型抗菌药物的靶点备受关注。了解aaRSs如何进化出高效的底物选择机制为开发有用的微生物蛋白质合成抑制剂提供了一条潜在途径。在此，我们讨论aaRSs对小分子的识别，以及这些机制的进化差异如何为针对这些必需的微生物酶设计抑制剂提供一种方法。
