Ross S A, Sánchez J L, Taboas J O
Department of Dermatology, University of Puerto Rico, School of Medicine, San Juan 00936.
Am J Dermatopathol. 1990 Aug;12(4):357-62. doi: 10.1097/00000372-199008000-00005.
Morphea and lichen sclerosus et atrophicus are cutaneous diseases that are manifest by an early edematous stage, followed later by sclerosis and atrophy. They share features with acrodermatitis chronica atrophicans and erythema chronicum migrans, diseases that have been linked to infection by the spirochete Borrelia burgdorferi. A modified silver stain was used to identify the presence of spirochetes in skin biopsy specimens of patients with morphea and lichen sclerosus et atrophicus. Spirochetal forms were identified in the lesional skin of 10 of 25 patients with morphea and in 10 of 21 cases of lichen sclerosus et atrophicus. These spiral forms of bacteria had a significant tendency to occur in early and fully developed lesions of morphea and in early lesions of lichen sclerosus et atrophicus, whereas they tended to be absent in lesions demonstrating late pathological changes.
硬斑病和萎缩性硬化性苔藓是一类皮肤病，早期表现为水肿阶段，随后出现硬化和萎缩。它们与慢性萎缩性肢端皮炎和慢性游走性红斑具有共同特征，而后两种疾病已被证实与伯氏疏螺旋体感染有关。采用改良银染色法来鉴定硬斑病和萎缩性硬化性苔藓患者皮肤活检标本中螺旋体的存在情况。在25例硬斑病患者的10例皮损中以及21例萎缩性硬化性苔藓患者的10例皮损中发现了螺旋体形态。这些螺旋形细菌在硬斑病的早期和完全发展期皮损以及萎缩性硬化性苔藓的早期皮损中具有显著的出现倾向，而在呈现晚期病理变化的皮损中往往不存在。
