通过烯醇醚的氧化重排形成螺环缩酮。

Spiroketals via oxidative rearrangement of enol ethers.

作者信息

Waller David L, Stephenson Corey R J, Wipf Peter

机构信息

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

出版信息

Org Biomol Chem. 2007 Jan 7;5(1):58-60. doi: 10.1039/b612992g. Epub 2006 Nov 14.

DOI:10.1039/b612992g

PMID:17164906

Abstract

Oxidative rearrangement of cyclic enol ethers leads to alpha-alkoxyesters. In the presence of a neighboring spiroether, this approach provides a stereoselective access to spiroketals. A modified proposal for the biosynthesis of acutumine is presented.

摘要

环状烯醇醚的氧化重排反应生成α-烷氧基酯。在相邻螺醚存在的情况下，该方法可立体选择性地合成螺缩酮。本文提出了一种对尖刺碱生物合成的改进方案。