一种合成烯醇醚和烯基氨基甲酸酯的有效方法。异吲哚并苯并氮杂卓生物碱、雷诺胺和智利宁的全合成。
An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine.
作者信息
Fuwa Haruhiko, Sasaki Makoto
机构信息
Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
出版信息
Org Biomol Chem. 2007 Jun 21;5(12):1849-53. doi: 10.1039/b706087d. Epub 2007 May 16.
DOI:10.1039/b706087d
PMID:17551632
Abstract
An efficient method for the synthesis of enol ethers and enecarbamates has been developed based on catalytic hydrosilane reduction of alpha-phosphonoxy enol ethers and alpha-phosphonoxy enecarbamates. This method has been applied to the total syntheses of two isoindolobenzazepine alkaloids, lennoxamine and chilenine.
摘要
基于α-膦酰氧基烯醇醚和α-膦酰氧基烯基氨基甲酸酯的催化硅烷还原反应，开发了一种合成烯醇醚和烯基氨基甲酸酯的有效方法。该方法已应用于两种异吲哚并苯并氮杂卓生物碱——勒诺胺和智利宁的全合成。
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