Sultan Shahnaz, Spector Jeremy, Mitchell Robert M
Department of Medicine, University of Florida Medical Center and Malcolm Randall Veterans Affairs Medical Center, Gainesville, Fla 32605, USA.
Mayo Clin Proc. 2006 Dec;81(12):1630-1. doi: 10.4065/81.12.1630.
Since the US Food and Drug Administration banned the use of dietary supplements containing ephedra in February 2004, numerous "ephedra-free" weight-loss products have appeared on the market. Many of these supplements contain compounds such as bitter orange that are similar in structure and action to ephedra. We describe a patient in whom ischemic colitis developed 1 week after initiation of a bitter orange-containing weight-loss supplement. The patient had no other predisposing factors, and discontinuation of the supplement led to immediate improvement and ultimate resolution of her symptoms. Both consumers and health care professionals should be aware of the potential harm that bitter orange-containing dietary supplements can cause and report such adverse events to the US Food and Drug Administration.
自2004年2月美国食品药品监督管理局禁止使用含麻黄的膳食补充剂以来，市场上出现了众多“无麻黄”的减肥产品。这些补充剂中有许多含有与麻黄结构和作用相似的化合物，如苦橙。我们描述了一名患者，在开始服用含苦橙的减肥补充剂1周后发生了缺血性结肠炎。该患者没有其他诱发因素，停用补充剂后症状立即改善并最终消失。消费者和医护人员都应意识到含苦橙的膳食补充剂可能造成的潜在危害，并向美国食品药品监督管理局报告此类不良事件。
