Hexsel Doris, Mazzuco Rosemari, Dal'Forno Taciana, Zechmeister Debora
Doris Hexsel Clínica Dermatológica, Porto Alegre, Brazil.
J Cosmet Dermatol. 2005 Jun;4(2):111-6. doi: 10.1111/j.1473-2165.2005.40212.x.
Both retinoid acid (RA) chemical peeling and microdermabrasion are minimally invasive procedures recently developed for the treatment of photoaging. The efficacy of each procedure has been proved, but the results of the combination of these two methods have not been studied until now.
To assess and compare the efficacy of microdermabrasion followed by a 5% RA chemical peel with that of a 5% RA chemical peel alone.
Six female patients with moderate degrees of photodamage were evaluated. Three submitted to microdermabrasion followed by the application of a 5% RA chemical peel and three submitted to a 5% RA chemical peel alone. Each patient underwent three treatment sessions, with intervals of 7-10 days. Photographs were taken, and both biopsies and histological assessments were carried out, before treatment and 7 days after the final treatment session.
In the opinion of the patients, in both groups there was improvement in the texture, pigmentation, and appearance of the treated skin, and this was confirmed with the assessment of the pre- and post-treatment photographs. The combination of microdermabrasion followed by a 5% RA peel showed slightly greater improvement in the histological alterations resulting from photoaging. Conclusion Both methods, microdermabrasion followed by a 5% RA chemical peel and a 5% RA chemical peel alone are effective in the treatment of photoaging.
维甲酸（RA）化学剥脱术和微晶磨皮术都是最近开发的用于治疗光老化的微创程序。每种程序的疗效都已得到证实，但这两种方法联合使用的效果至今尚未研究。
评估并比较微晶磨皮术后联合5% RA化学剥脱术与单纯5% RA化学剥脱术的疗效。
对6名中度光损伤的女性患者进行评估。3名患者先接受微晶磨皮术，然后应用5% RA化学剥脱术，另外3名患者仅接受5% RA化学剥脱术。每位患者接受3次治疗，间隔7 - 10天。在治疗前和最后一次治疗后7天拍摄照片，并进行活检和组织学评估。
患者认为，两组患者治疗后的皮肤质地、色素沉着和外观均有改善，治疗前后照片的评估证实了这一点。微晶磨皮术后联合5% RA剥脱术在光老化引起的组织学改变方面显示出稍大的改善。结论：微晶磨皮术后联合5% RA化学剥脱术和单纯5% RA化学剥脱术这两种方法在治疗光老化方面均有效。
