Knyazev G G, Knyazeva G B, Tolochko Z S
Laboratory of Neuromorphology, Institute of Physiology, Academy of Medical Sciences, Novosibirsk, U.S.S.R.
Neuroscience. 1991;42(2):555-60. doi: 10.1016/0306-4522(91)90397-7.
The results of the present study, in the rat and cat, indicate that not only a lesion of peripheral nerve or capsaicin pretreatment but also pharmacological deafferentation with local anaesthetic or disruption of the connections between primary sensory neurons and the central nervous system are effective in producing dystrophic changes in tissues. These effects of deafferentation do not seem to depend on the sympathetic or parasympathetic efferents. Dystrophic changes are connected with microcirculation disturbances: slow down of local blood flow, elevation of the vascular permeability, oedema and leucocyte infiltration. The findings indicate that capsaicin-sensitive primary sensory neurons are the afferent part of some reflex arrangement which participates in the regulation of microcirculation and the maintenance of trophic processes in peripheral tissues. The efferent part of this arrangement is unknown.
目前在大鼠和猫身上进行的研究结果表明，不仅外周神经损伤或辣椒素预处理，而且用局部麻醉药进行药理学去传入神经或破坏初级感觉神经元与中枢神经系统之间的联系，都能有效地在组织中产生营养不良性变化。这些去传入神经的作用似乎不依赖于交感或副交感传出神经。营养不良性变化与微循环障碍有关：局部血流减慢、血管通透性升高、水肿和白细胞浸润。研究结果表明，对辣椒素敏感的初级感觉神经元是某种反射机制的传入部分，该机制参与外周组织微循环的调节和营养过程的维持。这种机制的传出部分尚不清楚。
