Zbuk Kevin M, Eng Charis
Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Nat Rev Cancer. 2007 Jan;7(1):35-45. doi: 10.1038/nrc2037. Epub 2006 Dec 14.
Cancer phenomics, the systematic acquisition and objective documentation of host and/or somatic cancer phenotypic data at many levels, is a young field compared with other molecular-based 'omics'. Two relatively advanced phenomic paradigms are associated with phosphatase and tensin homologue (PTEN) and rearranged during transfection (RET), genes that are associated with cancer predisposition syndromes in addition to developmental disorders. The phenomic characterization of PTEN and RET underscores the importance of incorporating robust phenomics into the host 'omic' profile, and shows that the evolution of phenomics will be crucial to the advancement of personalized medicine.
癌症表型组学是一个与其他基于分子的“组学”相比还很年轻的领域，它涉及在多个层面系统获取并客观记录宿主和/或体细胞癌症的表型数据。两个相对先进的表型组学范式与磷酸酶和张力蛋白同源物（PTEN）以及转染时重排（RET）基因相关，这些基因除了与发育障碍有关外，还与癌症易感综合征相关。PTEN和RET的表型组学特征强调了将强大的表型组学纳入宿主“组学”图谱的重要性，并表明表型组学的发展对于个性化医疗的进步至关重要。
