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[重组人促红细胞生成素刺激接受重复血液透析治疗的肾性贫血患者胎儿血红蛋白的合成]

[Recombinant human erythropoietin stimulates synthesis of fetal hemoglobin in patients with renal anemia treated by repeated hemodialysis].

作者信息

Hanicki Z, Sułowicz W, Stepniewski M, Kuźniewski M, Kraśniak A, Kopeć J, Cieszkowska U, Solarska K

机构信息

Kliniki Nefrologii AM w Krakowie.

出版信息

Pol Arch Med Wewn. 1991 Jun;85(6):352-5.

PMID:1716757
Abstract

Effect of intravenously administered recombinant human erythropoietin (rHu EPO) on haemoglobin (Hb) level, haematocrit (Ht), reticulocyte count and foetal haemoglobin (HbF) concentration was assessed in 10 patients with anaemia, treated by repeated haemodialysis due to end-stage kidney. As compared to the initial values, erythropoietin treatment brought about a significant increase in all the parameters examined. During the subsequent therapy with lower, supporting doses of erythropoietin, the elevated HbF values fell back to normal, whereas the higher level of total Hb and Ht were maintained.

摘要

对10例因终末期肾病接受反复血液透析治疗的贫血患者,评估静脉注射重组人促红细胞生成素(rHu EPO)对血红蛋白(Hb)水平、血细胞比容(Ht)、网织红细胞计数和胎儿血红蛋白(HbF)浓度的影响。与初始值相比,促红细胞生成素治疗使所有检测参数均显著增加。在随后使用较低维持剂量促红细胞生成素的治疗过程中,升高的HbF值回落至正常,而总Hb和Ht的较高水平得以维持。

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1
[Recombinant human erythropoietin stimulates synthesis of fetal hemoglobin in patients with renal anemia treated by repeated hemodialysis].[重组人促红细胞生成素刺激接受重复血液透析治疗的肾性贫血患者胎儿血红蛋白的合成]
Pol Arch Med Wewn. 1991 Jun;85(6):352-5.
2
Effect on hemoglobin F synthesis by erythropoietin in patients with anemia of end-stage renal disease maintained by chronic hemodialysis.促红细胞生成素对终末期肾病慢性血液透析维持性贫血患者血红蛋白F合成的影响。
Nephron. 1992;60(3):371. doi: 10.1159/000186785.
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Correction of anaemia in haemodialysis patients with recombinant human erythropoietin.用重组人促红细胞生成素纠正血液透析患者的贫血
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[Activity of selected neutrophil enzymes of patients maintained on hemodialysis and treated with erythropoietin (rHu EPO)].
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Recombinant human erythropoietin stimulates synthesis of fetal haemoglobin in haemodialysed patients with anaemia due to end-stage kidney.重组人促红细胞生成素可刺激因终末期肾病而贫血的血液透析患者合成胎儿血红蛋白。
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Human recombinant erythropoietin in the treatment of anaemia in chronic haemodialysis patients.
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7
[Human recombinant erythropoietin (rH-EPO) in chronic hemodialysis patients].慢性血液透析患者中的重组人促红细胞生成素(rH-EPO)
Rev Med Chil. 1990 Jun;118(6):629-34.
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Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis.重组DNA衍生的人促红细胞生成素对维持性慢性血液透析患者贫血的影响。
Lancet. 1986 Nov 22;2(8517):1175-8. doi: 10.1016/s0140-6736(86)92192-6.
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[Erythropoietin-beta in the treatment of anemia in patients with chronic renal insufficiency].促红细胞生成素-β治疗慢性肾功能不全患者贫血
Med Pregl. 2001 May-Jun;54(5-6):235-40.
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[Human recombinant erythropoietin in the treatment of anemia in patients on long-term hemodialysis].
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