Tannenbaum Steven R, White Forest M
Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
ACS Chem Biol. 2006 Nov 21;1(10):615-8. doi: 10.1021/cb600439h.
Signal transduction from nitric oxide (NO) is important in physiological processes such as smooth muscle relaxation and neurotransmission. NO signaling occurs through a variety of mechanisms, including S-nitrosylation (SNO) of sulfhydryl groups in protein. A paper in this issue of the journal dissects the regulatory system involved in SNO of caspase-3 and highlights the need for more direct investigations of the complex biological regulation by NO signaling.
一氧化氮（NO）介导的信号转导在平滑肌舒张和神经传递等生理过程中起着重要作用。NO信号通过多种机制发生，包括蛋白质中巯基的S-亚硝基化（SNO）。本期杂志上的一篇论文剖析了caspase-3的SNO所涉及的调节系统，并强调需要对NO信号复杂的生物学调节进行更直接的研究。
