Khan K N, Nakata K, Kusumoto Y, Shima M, Ishii N, Koji T, Nagataki S
First Department of Internal Medicine, School of Medicine, Nagasaki University, Japan.
Cancer Res. 1991 Oct 15;51(20):5667-71.
The serial changes in serum hepatic enzyme activities by transcatheter arterial embolization (TAE) were analyzed in 17 patients with hepatocellular carcinoma to estimate the contribution to the value by the damage of tumor or nontumorous hepatic cells. The serum levels of relatively tumor-specific fructose 1,6-diphosphate (FDP) aldolase were elevated after TAE in the cases of both superselective and nonsuperselective TAE that were performed from the segmental and the nonsegmental hepatic artery, respectively, but we found the marked elevation of FDP aldolase in the cases of the superselective TAE. In contrast, the non-tumor-specific fructose 1-phosphate (F1P) aldolase was markedly elevated only in the cases of nonsuperselective TAE. The total amount of FDP aldolase released by TAE correlated significantly with the integrated tumor tissue volume (P less than 0.005), whereas the total amount of F1P aldolase output correlated significantly with the integrated nontumorous tissue volume (P less than 0.005) as defined by lipiodol accumulation on computerized tomography scan. The consequent changes in the total nontumorous liver volumes after TAE were also analyzed by the follow-up computerized tomography scan. The nonsuperselective TAE caused the significant total nontumorous liver atrophy when compared with the superselective TAE. The progression of the total nontumorous liver atrophy correlated significantly with F1P aldolase output by TAE (P less than 0.001) but not with FDP aldolase output. These results suggest that the outputs of FDP and F1P aldolase are useful to estimate the degree of the tumorous and nontumorous tissue damage by TAE, respectively, and F1P aldolase output can be used to predict the progression of liver atrophy caused by TAE.
对17例肝细胞癌患者经肝动脉栓塞术（TAE）后血清肝酶活性的系列变化进行了分析，以评估肿瘤或非肿瘤性肝细胞损伤对其值的影响。分别从肝段和非肝段肝动脉进行超选择性和非超选择性TAE后，血清中相对肿瘤特异性的果糖1,6 -二磷酸（FDP）醛缩酶水平均升高，但我们发现超选择性TAE病例中FDP醛缩酶显著升高。相比之下，非肿瘤特异性的果糖1 -磷酸（F1P）醛缩酶仅在非超选择性TAE病例中显著升高。TAE释放的FDP醛缩酶总量与肿瘤组织总体积显著相关（P小于0.005），而F1P醛缩酶输出总量与非肿瘤组织总体积显著相关（P小于0.005），非肿瘤组织总体积通过计算机断层扫描上的碘油积聚来定义。还通过随访计算机断层扫描分析了TAE后非肿瘤性肝脏总体积的后续变化。与超选择性TAE相比，非超选择性TAE导致非肿瘤性肝脏显著萎缩。非肿瘤性肝脏萎缩的进展与TAE的F1P醛缩酶输出显著相关（P小于0.001），但与FDP醛缩酶输出无关。这些结果表明，FDP和F1P醛缩酶的输出分别有助于评估TAE对肿瘤和非肿瘤组织的损伤程度，并且F1P醛缩酶输出可用于预测TAE引起的肝脏萎缩进展。
