Wang Shiying, Zhuang Liping, Meng Zhiqiang
Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University, 130 Dong An Road, Shanghai 200032, China.
ISRN Gastroenterol. 2013 Jul 1;2013:526024. doi: 10.1155/2013/526024. Print 2013.
Objective. To identify the efficiency and safety of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol (PEI) for patients with hepatocellular carcinoma (HCC) more than 3 cm in diameter in comparison with those of transcatheter arterial chemoembolization monotherapy. Methods. All databases were searched up to February 22, 2013. The literature retrieval was conducted through Pubmed, Web of Science, and Cochrane Library. We also searched Chinese databases, including Chinese National Knowledge Infrastructure (CNKI), Chinese Biology Medicine (CBM), Wanfang database, and VIP Database for Chinese Technical Periodicals without language limitations. Results. Based on the criteria, we found 12 RCTs including 825 patients. Our results showed that TACE combined with PEI therapy compared with TACE monotherapy improved overall survival and tumor response. Conclusion. The combination of TACE and PEI compared with TACE monotherapy improved overall survival rates and tumor response of patients with large HCC. Besides, larger and more methodologically rigorous clinical trials are needed to confirm this outcome.
目的。比较经动脉化疗栓塞术（TACE）联合经皮乙醇注射（PEI）与单纯经动脉化疗栓塞术治疗直径大于3厘米的肝细胞癌（HCC）患者的有效性和安全性。方法。检索截至2013年2月22日的所有数据库。通过PubMed、科学网和考克兰图书馆进行文献检索。我们还检索了中文数据库，包括中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方数据库和维普中文科技期刊数据库，无语言限制。结果。根据纳入标准，我们找到了12项随机对照试验，共825例患者。我们的结果表明，与单纯TACE治疗相比，TACE联合PEI治疗可提高总生存率和肿瘤反应率。结论。与单纯TACE治疗相比，TACE联合PEI治疗可提高大肝癌患者的总生存率和肿瘤反应率。此外，需要更大规模、方法学上更严谨的临床试验来证实这一结果。
