Loguercio C, Costato D, Del Vecchio Blanco C
Cattedra di Fisiopatologia Digestiva, I Medical School, Naples, Italy.
Digestion. 1991;48(3):128-33. doi: 10.1159/000200684.
Previous works have documented that pentagastrin has a stimulatory effect on salivary secretion. In this paper, we have studied the action of caerulein, a peptide that has an active gastrin-like terminal tetrapeptide, on salivary secretion in man. Our data documented that caerulein and pentagastrin have similar excitatory effect on gastric secretion in man, but different actions on salivary flow. Caerulein, at increasing doses, inhibits salivary flow, but not the secretion of amylase; this effect is statistically significant at 0.5 micrograms/kg/h which is the same dose that maximally stimulates gastric secretion. The inhibitory effect of caerulein was not reversed by previous injection of papaverin.
先前的研究记录了五肽胃泌素对唾液分泌有刺激作用。在本文中，我们研究了蛙皮素（一种具有活性胃泌素样末端四肽的肽）对人体唾液分泌的作用。我们的数据表明，蛙皮素和五肽胃泌素对人体胃液分泌有相似的兴奋作用，但对唾液分泌的作用不同。随着剂量增加，蛙皮素会抑制唾液分泌，但不影响淀粉酶的分泌；在0.5微克/千克/小时时这种作用具有统计学意义，而该剂量也是最大程度刺激胃液分泌的剂量。先前注射罂粟碱并不能逆转蛙皮素的抑制作用。
