Kisfalvi I
Digestion. 1979;19(5):315-21. doi: 10.1159/000198377.
The inhibitory effects of intravenous infusions of secretin, glucagon and caerulein on the gastric acid response to bombesin were studied in 8 duodenal ulcer patients. Bombesin was found to be a very potent stimulator of gastric acid secretion in patients with duodenal ulcer. There were no significant differences in acid outputs per 15-min period between bombesin infused in a dose of 0.9 microgram/kg/h and pentagastrin infusion administered in a maximal dose, at a rate of 6.0 microgram/kg/h. Secretin (1 U/kg/h), glucagon (30 microgram/kg/h) and caerulein (0.1 microgram/kg/h) produced significant decreases in gastric acid secretion evoked by bombesin given in a dose of 0.9 microgram/kg/h. Percentages of inhibition were 48.6, 45.2 and 35.5, respectively. It is supposed that secretin and glucagon given in pharmacological doses are capable of interfering with the action of gastrin released from antrum by means of bombesin on the parietal cell by noncompetitive kinetics. Caerulein administered in a pharmacological dosis, however, can inhibit the effect of gastrin released by bombesin on the parietal cells by a competitive kinetic.
在8例十二指肠溃疡患者中研究了静脉输注促胰液素、胰高血糖素和蛙皮素对蛙皮素引起的胃酸反应的抑制作用。发现蛙皮素是十二指肠溃疡患者胃酸分泌的一种非常有效的刺激物。以0.9微克/千克/小时的剂量输注蛙皮素与以6.0微克/千克/小时的最大剂量输注五肽胃泌素时，每15分钟的酸分泌量没有显著差异。促胰液素（1单位/千克/小时）、胰高血糖素（每30微克/千克/小时）和蛙皮素（0.1微克/千克/小时）可使以0.9微克/千克/小时的剂量给予的蛙皮素引起的胃酸分泌显著减少。抑制百分比分别为48.6%、45.2%和35.5%。推测药理剂量的促胰液素和胰高血糖素能够通过非竞争性动力学干扰由蛙皮素从胃窦释放的胃泌素对壁细胞的作用。然而，以药理剂量给予的蛙皮素可通过竞争性动力学抑制由蛙皮素释放的胃泌素对壁细胞的作用。
