Whitehead Nedra S, Leiker Richard
Research Triangle Institute International, Social and Statistical Sciences, 2951 Flowers Rd, Suite 119, Atlanta, GA 30341, USA.
Prev Chronic Dis. 2007 Jan;4(1):A05. Epub 2006 Dec 15.
Blood lead concentrations among children aged 6 years and younger become a concern at 10 microg/dL (0.48 micromol/L) or higher. The authors' objective was to determine whether initial blood lead concentrations of 10-19 microg/dL (0.48-0.96 micromol/L) declined among children aged 3 years and younger and whether the magnitude of decline was associated with the case management protocol of the state or local childhood lead poisoning prevention program.
The authors analyzed childhood blood lead surveillance data from 1994 through 1995 and case management protocols from six states that reported the results of all blood lead tests. The study included 2109 children aged 2 years or younger who had a venous blood lead concentration of 10-19 microg/dL (0.48-0.96 micromol/L) and a follow-up venous blood lead test within 3 to 12 months.
Overall, blood lead concentrations increased by 0.25 microg/dL (0.01 micromol/L) between the time of the initial elevated blood lead test and the follow-up test, but concentrations declined by 1.96 microg/dL (0.09 micromol/L) among children covered by a case management protocol that included a home visit and by 0.92 microg/dL (0.04 micromol/L) among those covered by a protocol that included a lead source investigation. The decline remained significant after we adjusted for the child's age.
These findings suggest that childhood lead prevention programs should consider focusing their efforts on home visits and lead source investigations.
6岁及以下儿童血铅浓度达到10微克/分升(0.48微摩尔/升)或更高时便会引发关注。作者的目的是确定3岁及以下儿童初始血铅浓度在10 - 19微克/分升(0.48 - 0.96微摩尔/升)之间是否会下降,以及下降幅度是否与州或地方儿童铅中毒预防项目的病例管理方案相关。
作者分析了1994年至1995年期间儿童血铅监测数据以及六个报告了所有血铅检测结果的州的病例管理方案。该研究纳入了2109名2岁及以下儿童,他们的静脉血铅浓度为10 - 19微克/分升(0.48 - 0.96微摩尔/升),并在3至12个月内进行了后续静脉血铅检测。
总体而言,从初始血铅检测结果升高到后续检测期间,血铅浓度上升了0.25微克/分升(0.01微摩尔/升),但在包含家访的病例管理方案覆盖的儿童中,血铅浓度下降了1.96微克/分升(0.09微摩尔/升),在包含铅源调查的方案覆盖的儿童中下降了0.92微克/分升(0.04微摩尔/升)。在对儿童年龄进行调整后,下降仍然显著。
这些发现表明,儿童铅预防项目应考虑将工作重点放在家访和铅源调查上。