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1992 - 2002年大巴黎地区铅中毒或有铅中毒风险儿童的随访情况

Follow-up of children suffering from lead poisoning or at risk of lead poisoning in Greater Paris, 1992--2002.

作者信息

Rollin L, Carré N, Garnier R

机构信息

Cellule interrégionale d'épidémiologie d'Ile de France, institut de veille sanitaire, 58-62, rue de Mouzaïa, 75935 Paris cedex 19, France.

出版信息

Rev Epidemiol Sante Publique. 2008 Dec;56(6):391-7. doi: 10.1016/j.respe.2008.08.002. Epub 2008 Nov 13.

Abstract

BACKGROUND

It is essential for children suffering from or at risk of lead poisoning to have regular follow-up, and specifically for their blood lead (Pb) levels to be monitored. The present study assessed the occurrence of late follow-up testing of blood lead levels in children in Greater Paris, and factors related to such delays.

METHODS

Since 1992, the SSSIILF has been systematically recording data on lead levels in blood tests conducted for screening and follow-up in Greater Paris. For Pb greater or equal to 45 microg/dL (Group 4), a further blood lead test has to be done within three weeks. For levels of 25 microg/dL < or = Pb < 45 microg/dL (Group 3) and 10 microg/dL < or = Pb < 25 microg/dL (Group 2), a second test must be done within 6 months. For Pb less than 10 microg/dL combined with one or more risk factors (Group 1: children at risk of poisoning), a second test is required within 6 to 12 months. Children aged 1 to 6 years who were screened between 1992 and 2002 were selected. The occurrence of late follow-up testing was estimated, and the independent effect of each variable associated with a delay was measured using a logistic regression model.

RESULTS

Delays in re-testing were reported for 66.9% of Group 4 children (n=356), 45.3% of Group 3 children (n=921), 74.1% of Group 2 children (n=5,466), and 88.7% of Group 1 children (n=15,612). In the three groups with Pb greater or equal to 10 microg/dL, there was better follow-up (i.e. less delay to re-testing) for children screened most recently, those whose initial blood lead test results were elevated, those who lived in sub-standard housing built before 1949, and those who lived in suburban districts of Paris. The delay was longer for children aged 4 to 6 compared to younger children. When the size of the group was large enough, these differences were significant. In Group 1, similar results were observed except for a home address in a suburban district. Furthermore, follow-up was better for children of Sub-Saharan African parents, children whose initial prescription had been issued by a "PMI" mother/child healthcare centre and children from large families.

CONCLUSION

Despite substantial delays in carrying out follow-up blood lead level testing, these delays were shorter for the populations with the greatest exposure.

摘要

背景

对于患有铅中毒或有铅中毒风险的儿童而言,定期随访至关重要,尤其要监测他们的血铅水平。本研究评估了大巴黎地区儿童血铅水平后期随访检测的情况以及与此类延迟相关的因素。

方法

自1992年以来,SSSIILF一直在系统记录大巴黎地区为筛查和随访而进行的血液检测中铅水平的数据。对于血铅水平大于或等于45微克/分升的儿童(第4组),必须在三周内进行进一步的血铅检测。对于血铅水平在25微克/分升<或 =血铅<45微克/分升的儿童(第3组)以及血铅水平在10微克/分升<或 =血铅<25微克/分升的儿童(第2组),必须在6个月内进行第二次检测。对于血铅水平低于10微克/分升且伴有一个或多个风险因素的儿童(第1组:有中毒风险的儿童),需要在6至12个月内进行第二次检测。选取了1992年至2002年间接受筛查的1至6岁儿童。评估了后期随访检测的情况,并使用逻辑回归模型测量了与延迟相关的每个变量的独立影响。

结果

报告显示,第4组儿童(n = 356)中有66.9%的儿童重新检测延迟,第3组儿童(n = 921)中有45.3%的儿童重新检测延迟,第2组儿童(n = 5466)中有74.1%的儿童重新检测延迟,第1组儿童(n = 15612)中有88.7%的儿童重新检测延迟。在血铅水平大于或等于10微克/分升的三组中,最近接受筛查的儿童、初始血铅检测结果升高的儿童、居住在1949年以前建造的不合标准住房中的儿童以及居住在巴黎郊区的儿童,其随访情况较好(即重新检测的延迟较短)。与年龄较小的儿童相比,4至6岁儿童的延迟时间更长。当组规模足够大时,这些差异具有统计学意义。在第1组中,除了家庭住址在郊区外,观察到了类似的结果。此外,撒哈拉以南非洲裔父母的儿童、初始处方由“PMI”母婴保健中心开具的儿童以及大家庭的儿童,其随访情况较好。

结论

尽管在进行血铅水平随访检测方面存在大量延迟,但对于暴露程度最高的人群,这些延迟时间较短。

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