Osborne D W, Ward A J, O'Neill K J
Drug Delivery R&D--Specialty Products, Upjohn Company, Kalamazoo, MI 49001-0199.
J Pharm Pharmacol. 1991 Jun;43(6):450-4.
Microemulsions with a 58:42 weight ratio of dioctyl sodium sulphosuccinate: octanol and containing 15, 35, and 68% water have been tested for their ability to transport glucose across human cadaver skin. A flow-through multisample skin diffusion cell showed that both the 35 and 68% water microemulsions caused enhanced (approximately 30-fold) transport of glucose. No transport was discernible for the 15% water microemulsion. Differences in percutaneous glucose transport were shown to parallel differences in the diffusion of water within the microemulsion vehicles before application to the skin.
对含有磺基琥珀酸二辛酯钠与辛醇重量比为58:42且含水量分别为15%、35%和68%的微乳剂进行了跨人尸体皮肤转运葡萄糖能力的测试。流通式多样品皮肤扩散池显示，含水量为35%和68%的微乳剂均能促进（约30倍）葡萄糖的转运。含水量为15%的微乳剂未观察到葡萄糖转运。结果表明，经皮葡萄糖转运的差异与微乳剂在应用于皮肤之前水在其中的扩散差异平行。
