[儿童单纯疱疹病毒感染的血清学检查]

[Serologic examination for childhood herpes simplex virus infection].

作者信息

Tang Jian-Ping, Yang Yu-Jia, Zhang Dan, Li Li-Ping

机构信息

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2006 Dec;8(6):476-8.

PMID:17178039

Abstract

OBJECTIVE

This study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplex virus (HSV) infection.

METHODS

Serum samples were collected from 2 436 outpatients and inpatients. The samples were divided into two groups. Group 1 consisted of 321 samples which were assayed for HSV-1 IgG, HSV-1 IgM, HSV-2 IgG or HSV-2 IgM antibody using herpes simplex virus antibody kits between January 2003 and November 2005. Group 2 consisted of 2115 samples which were assayed for HSV-2 IgG and IgM antibodies by TORCH testing between October 2004 and November 2005.

RESULTS

In Group 1, the total seroprevalence of HSV infection was 44.6%, with 38.9% being HSV-1 positive and 15.9% HSV-2 positive; HSV-IgM positivity was found in 41.1% and 25.5% were HSV-IgG positive; HSV-1 seroprevalence significantly increased with age (P < 0.05). In Group 2 the seroprevalence of HSV-2 infection was 1.9%; all of the samples were HSV-2 IgG positive.

CONCLUSIONS

HSV serologic examination is useful in the diagnosis of HSV infection in children.

摘要

目的

本研究旨在探讨血清学检查在儿童单纯疱疹病毒（HSV）感染诊断中的价值。

方法

收集2436例门诊和住院患者的血清样本。样本分为两组。第1组由321份样本组成，于2003年1月至2005年11月期间使用单纯疱疹病毒抗体试剂盒检测HSV-1 IgG、HSV-1 IgM、HSV-2 IgG或HSV-2 IgM抗体。第2组由2115份样本组成，于2004年10月至2005年11月期间通过TORCH检测检测HSV-2 IgG和IgM抗体。

结果

在第1组中，HSV感染的总血清阳性率为44.6%，其中HSV-1阳性率为38.9%，HSV-2阳性率为15.9%；HSV-IgM阳性率为41.1%，HSV-IgG阳性率为25.5%；HSV-1血清阳性率随年龄显著增加（P<0.05）。在第2组中，HSV-2感染的血清阳性率为1.9%；所有样本均为HSV-2 IgG阳性。