Kempermann Gerd
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Robert Rössle Strasse 10, 13125 Berlin, Germany.
Neuron. 2006 Dec 21;52(6):935-7. doi: 10.1016/j.neuron.2006.12.004.
In a new study in this issue of Neuron, Jakubs and colleagues report that adult-generated hippocampal granule cells develop particular functional properties when their birth is induced by epileptic seizures. The new neurons showed reduced excitatory synaptic input and decreased excitability. Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe.
在本期《神经元》杂志上的一项新研究中，雅库布斯及其同事报告称，当成年期产生的海马颗粒细胞由癫痫发作诱导产生时，它们会发展出特定的功能特性。这些新神经元的兴奋性突触输入减少，兴奋性降低。因此，它们的功能整合被调整到网络中占主导地位的功能状态。通过这种方式，成年神经发生可能有助于癫痫颞叶的网络稳态。
