Poss Kenneth D
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States.
Semin Cell Dev Biol. 2007 Feb;18(1):36-45. doi: 10.1016/j.semcdb.2006.11.009. Epub 2006 Nov 24.
A scientific and clinical prerogative of the 21st century is to stimulate the regenerative ability of the human heart. While the mammalian heart shows little or no natural regeneration in response to injury, certain non-mammalian vertebrates possess an elevated capacity for cardiac regeneration. Adult zebrafish restore ventricular muscle removed by surgical resection, events that involve little or no scarring. Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease.
激发人类心脏的再生能力是21世纪的一项科学和临床使命。虽然哺乳动物的心脏在受到损伤时几乎没有或完全没有自然再生能力，但某些非哺乳动物脊椎动物却具有较高的心脏再生能力。成年斑马鱼能修复因手术切除而移除的心室肌肉，且这些过程几乎不会产生疤痕。最近的研究已开始揭示这一再生过程的细胞和分子机制，这些机制对人类心脏生物学和疾病具有令人兴奋的意义。
