Mitra Arkadeep, Mandal Subhadeep, Banerjee Kalyan, Ganguly Nilanjan, Sasmal Pramit, Banerjee Durba, Gupta Shreyasi
Department of Zoology, City College, 102/1, Raja Rammohan Sarani, Kolkata, 700009, West Bengal, India.
Department of Zoology, Trivenidevi Bhalotia College (Affiliated to Kazi Nazrul University), College Para Rd, Raniganj, 713347, West Bengal, India.
Curr Cardiol Rep. 2025 Jan 10;27(1):15. doi: 10.1007/s11886-024-02162-y.
This review investigates how post-injury cellular signaling and energy metabolism are two pivotal points in zebrafish's cardiomyocyte cell cycle re-entry and proliferation. It seeks to highlight the probable mechanism of action in proliferative cardiomyocytes compared to mammals and identify gaps in the current understanding of metabolic regulation of cardiac regeneration.
Metabolic substrate changes after birth correlate with reduced cardiomyocyte proliferation in mammals. Unlike adult mammalian hearts, zebrafish can regenerate cardiomyocytes by re-entering the cell cycle, characterized by a metabolic switch from oxidative metabolism to increased glycolysis. Zebrafish provide a valuable model for studying metabolic regulation during cell cycle re-entry and cardiac regeneration. Proliferative cardiomyocytes have upregulated Notch, hippo, and Wnt signaling and decreased ROS generation, DNA damage in different zebrafish cardiac regeneration models. Understanding the correlation between metabolic switches during cell cycle re-entry of already differentiated zebrafish cardiomyocytes is being increasingly recognized as a critical factor in heart regeneration. Zebrafish studies provide insights into metabolic adaptations during heart regeneration, emphasizing the importance of a metabolic switch. However, there are mechanistic gaps, and extensive studies are required to aid in formulating therapeutic strategies for cardiac regenerative medicine.
本综述探讨损伤后细胞信号传导和能量代谢如何成为斑马鱼心肌细胞重新进入细胞周期和增殖的两个关键点。它旨在突出与哺乳动物相比，增殖性心肌细胞可能的作用机制，并找出当前对心脏再生代谢调节理解中的差距。
出生后代谢底物的变化与哺乳动物心肌细胞增殖减少相关。与成年哺乳动物心脏不同，斑马鱼可以通过重新进入细胞周期来再生心肌细胞，其特征是代谢从氧化代谢转变为糖酵解增加。斑马鱼为研究细胞周期重新进入和心脏再生过程中的代谢调节提供了有价值的模型。在不同的斑马鱼心脏再生模型中，增殖性心肌细胞的Notch、河马和Wnt信号上调，活性氧生成减少，DNA损伤减少。理解已分化的斑马鱼心肌细胞在细胞周期重新进入过程中代谢转换之间的相关性越来越被认为是心脏再生的关键因素。斑马鱼研究为心脏再生过程中的代谢适应提供了见解，强调了代谢转换的重要性。然而，存在机制上的差距，需要进行广泛的研究以帮助制定心脏再生医学的治疗策略。
