Gerok W, Blum H E, Offensperger W, Offensperger S, Andus T, Gross V, Heinrich P C
Medizinische Universitätsklinik, Freiburg, Bundesrepublik Deutschland.
Naturwissenschaften. 1991 Jun;78(6):241-9. doi: 10.1007/BF01134350.
By two exemplary clinical situations--acute viral hepatitis, acute-phase reaction of the liver--the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.
