氯氧喹（5-氯喹啉-8-醇）对结核分枝杆菌的体外活性。
In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.
作者信息
Hongmanee Poonpilas, Rukseree Kamolchanok, Buabut Benjamas, Somsri Boontiwa, Palittapongarnpim Prasit
机构信息
Division of Microbiology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
出版信息
Antimicrob Agents Chemother. 2007 Mar;51(3):1105-6. doi: 10.1128/AAC.01310-06. Epub 2006 Dec 18.
Abstract
The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.
摘要
研究了氯氧喹（5-氯喹啉-8-醇）对9株结核分枝杆菌标准菌株和150株临床分离株的体外活性。最低抑菌浓度（MIC）范围为0.062至0.25微克/毫升。MIC50和MIC90分别为0.125和0.25微克/毫升。这些结果表明，氯氧喹即使对多重耐药菌株也表现出良好的抗结核活性。
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