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侵袭性曲霉病的两种非侵入性诊断工具:(1-3)-β-D-葡聚糖和半乳甘露聚糖检测

Two non-invasive diagnostic tools for invasive aspergilosis: (1-3)-beta-D-glucan and the galactomannan assay.

作者信息

Kelaher Amy

机构信息

Department of Medical and Research Technology, University of Maryland School of Medicine, 100 Penn Street-AHB Room #435, Baltimore 21201, USA.

出版信息

Clin Lab Sci. 2006 Fall;19(4):222-4.

PMID:17181127
Abstract

Invasive aspergillosis (IA) is a serious cause of morbidity and mortality among immunocompromised patients. Prompt and non-invasive methods for diagnosing IA are needed to improve the management of this life-threatening infection in patients with hematological disorders. In summary, this retrospective review of studies performed on the two assays finds that both assays have high sensitivity and specificity but are more useful when used together as a diagnostic strategy for patients with invasive aspergillosis.

摘要

侵袭性曲霉病(IA)是免疫功能低下患者发病和死亡的重要原因。需要快速且非侵入性的IA诊断方法,以改善对血液系统疾病患者这种危及生命感染的管理。总之,对这两种检测方法进行的回顾性研究发现,这两种检测方法均具有高灵敏度和特异性,但作为侵袭性曲霉病患者的诊断策略联合使用时更有用。

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引用本文的文献

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Bloodstream infections are an improbable cause of positive serum (1,3)-β-D-glucan in hematology patients.血流感染不太可能是血液学患者血清(1,3)-β-D-葡聚糖呈阳性的原因。
Clin Vaccine Immunol. 2014 Sep;21(9):1357-9. doi: 10.1128/CVI.00214-14. Epub 2014 Jul 2.
2
The interaction between piperacillin/tazobactam and assays for Aspergillus galactomannan and 1,3-beta-D-glucan in patients without risk factors for invasive fungal infections.哌拉西林/他唑巴坦与曲霉半乳甘露聚糖和 1,3-β-D-葡聚糖检测在无侵袭性真菌感染危险因素患者中的相互作用。
Infection. 2010 Jun;38(3):217-21. doi: 10.1007/s15010-010-0003-6. Epub 2010 Mar 17.
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Contribution of the (1-->3)-beta-D-glucan assay for diagnosis of invasive fungal infections.
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