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血流感染不太可能是血液学患者血清（1,3）-β-D-葡聚糖呈阳性的原因。

Bloodstream infections are an improbable cause of positive serum (1,3)-β-D-glucan in hematology patients.

作者信息

Furfaro E, Mikulska M, Del Bono V, Guolo F, Minetto P, Gobbi M, Ghiso A, Bacigalupo A, Viscoli C

机构信息

Division of Infectious Diseases, IRCCS San Martino-IST University Hospital, Genoa, Italy

Division of Infectious Diseases, IRCCS San Martino-IST University Hospital, Genoa, Italy.

出版信息

Clin Vaccine Immunol. 2014 Sep;21(9):1357-9. doi: 10.1128/CVI.00214-14. Epub 2014 Jul 2.

DOI:10.1128/CVI.00214-14
PMID:24990906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4178577/
Abstract

Ninety-one serum samples from 51 hematology patients with bacteremia infections were tested for (1,3)-β-d-glucan (BG). Eleven samples (15%) from 7 patients (14%) were positive for BG. Of these 7 patients with positive BG results, 4 (8%) had invasive aspergillosis and 3 (6%) had no invasive fungal disease. Bacteremia was an unlikely cause of the false-positive BG results.

摘要

对51例患有菌血症感染的血液学患者的91份血清样本进行了（1,3）-β-d-葡聚糖（BG）检测。7例患者（14%）的11份样本（15%）BG检测呈阳性。在这7例BG结果为阳性的患者中，4例（8%）患有侵袭性曲霉病，3例（6%）没有侵袭性真菌病。菌血症不太可能是BG结果假阳性的原因。

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本文引用的文献

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Simultaneous increase in 1,3-β-D-glucan and procalcitonin levels in Pseudomonas aeruginosa infection.
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Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study.1,3-β-D-葡聚糖检测在菌血症中的反应性：一项前瞻性研究的有限证据。
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Can bacteraemia lead to false positive results in 1,3-beta-D-glucan test? Analysis of 83 bacteraemia episodes in high-risk patients for invasive fungal infections.菌血症会导致1,3-β-D-葡聚糖检测出现假阳性结果吗？对83例侵袭性真菌感染高危患者菌血症发作情况的分析。
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Difficulties in using 1,3-{beta}-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies--high frequency of false-positive results and their analysis.1,3-β-D-葡聚糖作为血液恶性肿瘤患者侵袭性真菌感染早期诊断的筛选试验存在困难——假阳性率高及其分析。
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Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.欧洲癌症研究与治疗组织/侵袭性真菌感染合作组和美国国立过敏与传染病研究所真菌病研究组（EORTC/MSG）共识组对侵袭性真菌病的修订定义。
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