Foucault Cédric, Brouqui Philippe
Service des Maladies Infectieuses et Tropicales, Hôpital Nord, Marseille, France.
FEMS Immunol Med Microbiol. 2007 Mar;49(2):173-83. doi: 10.1111/j.1574-695X.2006.00172.x. Epub 2006 Dec 13.
Antimicrobial misuse results in the development of resistance and superbugs. Over recent decades, resistance has been increasing despite continuing efforts to control it, resulting in increased mortality and cost. Many authorities have proposed local, regional and national guidelines to fight against this phenomenon, and the usefulness of these programmes has been evaluated. Multifaceted intervention seems to be the most efficient method to control antimicrobial resistance. Monitoring of bacterial resistance and antibiotic use is essential, and the methodology has now been homogenized. The implementation of guidelines and infection control measures does not control antimicrobial resistance and needs to be reinforced by associated measures. Educational programmes and rotation policies have not been evaluated sufficiently in the literature. Combination antimicrobial therapy is inefficient in controlling antimicrobial resistance.
抗菌药物的滥用导致了耐药性和超级细菌的出现。在最近几十年里，尽管一直在努力控制耐药性，但耐药性仍在不断增加，导致死亡率上升和成本增加。许多当局已经提出了地方、区域和国家层面的指南来应对这一现象，并且这些方案的有效性也得到了评估。多方面干预似乎是控制抗菌药物耐药性的最有效方法。监测细菌耐药性和抗生素使用情况至关重要，并且现在方法已经统一。指南和感染控制措施的实施并不能控制抗菌药物耐药性，需要通过相关措施加以强化。教育方案和轮岗政策在文献中尚未得到充分评估。联合抗菌治疗在控制抗菌药物耐药性方面效率低下。
