Maki Dennis G, Safdar Nasia, Ebert Steven C
Section of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Pharmacotherapy. 2007 Oct;27(10 Pt 2):121S-125S. doi: 10.1592/phco.27.10part2.121S.
Since the early development of antibiotics, antimicrobial resistance has continued to emerge as a formidable adversary in the fight against infectious disease. Once an issue confined to hospitals, antibiotic resistance has now invaded communities, targeting not only the immunocompromised patient, but also those who are immunocompetent. To stem this crisis, researchers have developed more powerful and more costly antibiotics, which have only complicated the resistance problem. Education of the patient and the prescriber, as well as antimicrobial stewardship programs, are necessary to avert a global antibiotic resistance catastrophe.
自从抗生素早期研发以来,抗菌药物耐药性在对抗传染病的斗争中持续成为一个强大的对手。抗生素耐药性曾经是仅限于医院的问题,现在已经侵入社区,不仅针对免疫功能低下的患者,也针对免疫功能正常的人。为了阻止这场危机,研究人员研发出了更强大、成本更高的抗生素,这只会让耐药性问题变得更加复杂。对患者和开处方者进行教育以及开展抗菌药物管理计划对于避免全球抗生素耐药性灾难是必要的。