Sano T, Vrontakis M E, Kovacs K, Asa S L, Friesen H G
Department of Pathology, St Micheal's Hospital, University of Toronto, Canada.
Arch Pathol Lab Med. 1991 Sep;115(9):926-9.
We investigated immunoreactivity for galanin, a 29-amino acid peptide, in formalin-fixed, paraffin-embedded sections of 123 neuroendocrine tumors. Galanin-immunoreactive cells were found in one of 12 hypothalamic gangliocytomas, nine of 18 adrenal pheochromocytomas, nine of 14 pituitary corticotroph adenomas, and one of two thymic endocrine tumors. In pheochromocytomas, galanin-immunoreactive cells were seen either singly or in clusters. In corticotroph adenomas, many tumor cells were positive for galanin, indicating colocalization of corticotropin and galanin in the same tumor cells. No galanin-immunoreactive cells were noted in four extra-adrenal paragangliomas; 10 medullary carcinomas of the thyroid; 35 endocrine tumors arising in the lung, pancreas, and gastrointestinal tract; and 28 pituitary adenomas composed of cells other than corticotrophs. In nontumorous counterparts of these neuroendocrine tumors, galanin immunoreactivity was observed in nerve cells of the hypothalamus, nerve fibers of the duodenum, and adenohypophyseal cells corresponding to corticotrophs. These findings indicate that galanin expression in neuroendocrine tumors is uncommon and restricted to some tumor types.
我们研究了123例神经内分泌肿瘤的福尔马林固定、石蜡包埋切片中甘丙肽（一种由29个氨基酸组成的肽）的免疫反应性。在12例下丘脑神经节细胞瘤中的1例、18例肾上腺嗜铬细胞瘤中的9例、14例垂体促肾上腺皮质激素腺瘤中的9例以及2例胸腺内分泌肿瘤中的1例中发现了甘丙肽免疫反应性细胞。在嗜铬细胞瘤中，可见单个或成群的甘丙肽免疫反应性细胞。在促肾上腺皮质激素腺瘤中，许多肿瘤细胞甘丙肽呈阳性，表明促肾上腺皮质激素和甘丙肽在同一肿瘤细胞中共定位。在4例肾上腺外副神经节瘤、10例甲状腺髓样癌、35例发生于肺、胰腺和胃肠道的内分泌肿瘤以及28例由非促肾上腺皮质激素细胞组成的垂体腺瘤中未发现甘丙肽免疫反应性细胞。在这些神经内分泌肿瘤的非肿瘤对应组织中，在下丘脑的神经细胞、十二指肠的神经纤维以及与促肾上腺皮质激素细胞相对应的腺垂体细胞中观察到了甘丙肽免疫反应性。这些发现表明，甘丙肽在神经内分泌肿瘤中的表达并不常见，且仅限于某些肿瘤类型。
