L-茶氨酸（N-乙基-L-谷氨酰胺）的神经药理学：一种可能具有神经保护和认知增强作用的药物。
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent.
作者信息
Nathan Pradeep J, Lu Kristy, Gray M, Oliver C
机构信息
Behavioural Neuroscience Laboratory, Department of Physiology, Monash Center for Brain and Behaviour, Monash University, Australia.
出版信息
J Herb Pharmacother. 2006;6(2):21-30.
L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies in animals suggest improvement in learning and memory. Overall, L-theanine displays a neuropharmacology suggestive of a possible neuroprotective and cognitive enhancing agent and warrants further investigation in animals and humans.
L-茶氨酸（N-乙基-L-谷氨酰胺）或茶氨酸是绿茶中特有的一种主要氨基酸。历史上，L-茶氨酸一直被报道为一种松弛剂，这促使人们对其药理学进行科学研究。动物神经化学研究表明，L-茶氨酸可提高大脑中血清素、多巴胺、γ-氨基丁酸（GABA）的水平，并且对α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）、海人藻酸和N-甲基-D-天冬氨酸（NMDA）受体具有微摩尔亲和力。此外，它已被证明可能通过对第1组代谢型谷氨酸受体的拮抗作用在动物模型中发挥神经保护作用。动物行为学研究表明其能改善学习和记忆。总体而言，L-茶氨酸显示出一种神经药理学特性，表明它可能是一种神经保护和认知增强剂，值得在动物和人类中进一步研究。
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