Snapinn Katherine W, Holmes Edward C, Young David S, Bernard Kristen A, Kramer Laura D, Ebel Gregory D
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA.
J Virol. 2007 Mar;81(5):2531-4. doi: 10.1128/JVI.02169-06. Epub 2006 Dec 20.
To determine the demographic history of West Nile virus (WNV) in North America, we employed a coalescent method to envelope coding region data sets for the NY99 and WN02 genotypes. Although the observed genetic diversities in both genotypes were of approximately the same age, the mean rate of epidemiological growth of the WN02 population was approximately three times that of the NY99 population, a finding compatible with the recent dominance of the former genotype. However, there has also been a marked decrease in the recent growth rate of WN02, suggesting that WNV has reached its peak prevalence in North America.
为了确定西尼罗河病毒(WNV)在北美的种群历史,我们采用了一种溯祖方法来分析NY99和WN02基因型包膜编码区数据集。尽管观察到的两种基因型的遗传多样性大致处于相同年代,但WN02种群的平均流行病学增长速率约为NY99种群的三倍,这一发现与前一种基因型近期的主导地位相符。然而,WN02的近期增长率也显著下降,这表明WNV在北美已达到流行高峰。