Ron Yonina, Ehrlich Rita, Axer-Siegel Ruth, Rosenblatt Irit, Weinberger Dov
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
Ophthalmologica. 2007;221(1):57-61. doi: 10.1159/000096524.
Subretinal hemorrhage is one of the most serious complications of exudative age-related macular degeneration (AMD). Treatment with vitreous surgery with or without plasminogen activator, fluid-gas exchange, or perfluorocarbon yields only a small improvement in visual acuity.
The files of 24 patients with submacular hemorrhage secondary to AMD who were treated by injection of perfluoropropane gas (C(3)F(8)) (11 patients) or sulfur hexafluoride (SF(6)) (13 patients) were reviewed for visual acuity before and after the procedure and time of treatment from onset of symptoms.
For the whole sample, pneumatic displacement led to a statistically significant improvement in mean visual acuity (p = 0.015). A significant difference between pre- and postoperative visual acuity was found for the patients treated with SF(6) (p = 0.034), but not for the patients treated with C(3)F(8) (p = 0.245).
The use of gas injection to displace submacular hemorrhage can significantly improve visual acuity.
视网膜下出血是渗出性年龄相关性黄斑变性（AMD）最严重的并发症之一。采用玻璃体手术联合或不联合纤溶酶原激活剂、液气交换或全氟碳治疗，视力仅有小幅改善。
回顾性分析24例继发于AMD的黄斑下出血患者的病历资料，这些患者接受了全氟丙烷气体（C(3)F(8)）注射治疗（11例）或六氟化硫（SF(6)）注射治疗（13例），记录手术前后的视力以及从症状出现到治疗的时间。
对于整个样本，气体置换使平均视力有统计学意义的显著改善（p = 0.015）。接受SF(6)治疗的患者术前和术后视力有显著差异（p = 0.034），但接受C(3)F(8)治疗的患者则无显著差异（p = 0.245）。
采用气体注射置换黄斑下出血可显著提高视力。
