Rowbotham D J, Milligan K, McHugh P
University Department of Anaesthesia, Leicester Royal Infirmary.
Br J Anaesth. 1991 Oct;67(4):421-5. doi: 10.1093/bja/67.4.421.
We investigated the effect of cisapride 20 mg given orally with MST 20 mg on the absorption of morphine in a double-blind, placebo-controlled study. Cisapride increased significantly both plasma concentrations of morphine after 1 h and peak concentrations. There was no significant change in time to peak concentrations, sedation scores or percentage decrease in pupil diameters. Plasma concentrations of amylase were increased in three patients in the MST-placebo group and three in the MST-cisapride group. One patient in the MST-cisapride group developed acute pancreatitis.
在一项双盲、安慰剂对照研究中，我们研究了口服20毫克西沙必利联合20毫克吗啡控释片（MST）对吗啡吸收的影响。西沙必利显著提高了1小时后吗啡的血浆浓度以及峰值浓度。达峰时间、镇静评分或瞳孔直径缩小百分比均无显著变化。在MST-安慰剂组和MST-西沙必利组中各有3名患者淀粉酶血浆浓度升高。MST-西沙必利组有1名患者发生了急性胰腺炎。
