Rowbotham D J, Parnacott S, Nimmo W S
University Department of Anaesthesia, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Eur J Clin Pharmacol. 1992;42(2):235-6. doi: 10.1007/BF00278493.
We have measured the effect of oral cisapride on paracetamol absorption in 12 healthy volunteers in a double-blind placebo-controlled study. Volunteers received paracetamol plus placebo, paracetamol plus cisapride 10 mg and paracetamol plus cisapride 20 mg. Mean plasma paracetamol AUC at 60 min were 1070, 1051 and 1031 micrograms.min.ml-1 and maximum paracetamol concentrations were 31.5, 29.3 and 27.4 micrograms.ml-1 respectively (no significant differences). There was no difference also in time to maximum paracetamol concentration [median (range) 30 (15-120), 30 (15-90) and 30 (15-60) min, respectively]. .
在一项双盲安慰剂对照研究中，我们测量了口服西沙必利对12名健康志愿者对乙酰氨基酚吸收的影响。志愿者分别接受对乙酰氨基酚加安慰剂、对乙酰氨基酚加10毫克西沙必利和对乙酰氨基酚加20毫克西沙必利。60分钟时对乙酰氨基酚的平均血浆药时曲线下面积分别为1070、1051和1031微克·分钟·毫升⁻¹，对乙酰氨基酚的最大浓度分别为31.5、29.3和27.4微克·毫升⁻¹（无显著差异）。对乙酰氨基酚达到最大浓度的时间也没有差异[中位数（范围）分别为30（15 - 120）、30（15 - 90）和30（15 - 60）分钟]。
