Becker Bénédicte, Bertrand Evelyne, Van Hoeck Jeannine, Verhaegen Godelieve, Rozenberg Serge, Delvigne Annick
IVF Centre, Department of Obstetrics-Gynaecology, University Hospital St Pierre, Free University of Brussels, Brussels, Belgium.
Int J Fertil Womens Med. 2006 Jul-Aug;51(4):163-9.
To compare the outcomes of conventional IVF and ICSI on sibling oocytes.
Retrospective analysis.
Performance of ICSI on part of the oocytes and IVF on the remaining portion during the same cycle (sibling oocytes).
135 couples (141 cycles) with male subfertility or with idiopathic infertility.
Globally, the fertilization rate was not different between the ICSI and IVF, however, in patients with severe teratospermia, it was higher after ICSI (56.2 vs. 44.2 %, p<0.05). The fertilization failure rate was higher in the IVF group than in the ICSI group, globally, (12.1 % vs 2.8 %, p = 0.005), as well in patients with severe teratospermia. In the latter group, a higher number of top quality embryos were obtained after ICSI than after IVF. Of 57 cycles with severe teratospermia, only ICSI-embryos were transferred in 24, while only IVF-embryos were transferred in 11, resulting respectively in 8 and 3 clinical pregnancies.
This study underscores that ICSI is useful in patients with teratospermia. Nevertheless, considering the chances of obtaining a successful fertilization after IVF and lower risk of chromosomal aberrations, we recommend performing both IVF and ICSI on sibling oocytes during the first treatment cycle in patients with teratospermia.
比较常规体外受精（IVF）和卵胞浆内单精子注射（ICSI）在同胞卵母细胞上的结局。
回顾性分析。
在同一周期内，对部分卵母细胞进行ICSI，其余部分进行IVF（同胞卵母细胞）。
135对夫妇（141个周期），患有男性不育或特发性不育。
总体而言，ICSI和IVF的受精率没有差异，然而，在严重畸形精子症患者中，ICSI后的受精率更高（56.2%对44.2%，p<0.05）。总体上，IVF组的受精失败率高于ICSI组（12.1%对2.8%，p = 0.005），严重畸形精子症患者也是如此。在后一组中，ICSI后获得的优质胚胎数量多于IVF后。在57个严重畸形精子症周期中，24个周期仅移植了ICSI胚胎，11个周期仅移植了IVF胚胎，分别导致8例和3例临床妊娠。
本研究强调ICSI对畸形精子症患者有用。然而，考虑到IVF后成功受精的机会以及染色体畸变风险较低，我们建议在畸形精子症患者的第一个治疗周期中，对同胞卵母细胞同时进行IVF和ICSI。
