Mühlhäusler B S
Early Origins of Adult Health Research Group, Sansom Research Institute, School of Pharmacy and Medical Science, Division of Health Sciences, University of South Australia, City East Campus, Adelaide, SA 5000, Australia.
J Neuroendocrinol. 2007 Jan;19(1):67-72. doi: 10.1111/j.1365-2826.2006.01505.x.
The concept of a functional foetal "appetite regulatory neural network" is a new and potentially critical one. There is a growing body of evidence showing that the nutritional environment to which the foetus is exposed during prenatal and perinatal development has long-term consequences for the function of the appetite-regulating neural network and therefore the way in which an individual regulates energy balance throughout later life. This is of particular importance in the context of evidence obtained from a wide range of epidemiological studies, which have shown that individuals exposed to an elevated nutrient supply before birth have an increased risk of becoming obese as children and adults. This review summarises the key pieces of experimental evidence, by our group and others, that have contributed to our current understanding of the programming of appetite, and highlights the important questions that are yet to be answered. It is clear that this area of research has the potential to generate, within the next few years, interventions that could begin to alleviate the adverse long-term consequences of being exposed to an elevated nutrient supply before birth.
功能性胎儿“食欲调节神经网络”的概念是一个新的且可能至关重要的概念。越来越多的证据表明，胎儿在产前和围产期发育过程中所处的营养环境，会对食欲调节神经网络的功能产生长期影响，进而影响个体在整个成年期调节能量平衡的方式。鉴于从广泛的流行病学研究中获得的证据，这一点尤为重要，这些研究表明，出生前接触高营养供应的个体在儿童期和成年期肥胖的风险增加。本综述总结了我们小组及其他团队的关键实验证据，这些证据有助于我们目前对食欲编程的理解，并突出了尚未解答的重要问题。很明显，在未来几年内，这一研究领域有可能产生一些干预措施，从而开始减轻出生前接触高营养供应所带来的长期不良后果。
