El-Zahabi Lara M N, Jamali Faek R, El-Hajj Ihab I, Naja Mohammed, Salem Ziad, Shamseddine Ali, El-Saghir Nagi S, Zaatari Ghazi, Geara Fady, Soweid Assaad M
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Gastrointest Endosc. 2007 Jan;65(1):89-96. doi: 10.1016/j.gie.2006.05.009.
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is associated with Helicobacter pylori infection, and regression of the tumor has been described after its eradication.
To determine the value of EUS, in addition to other clinical/endoscopic features, in predicting the response of low-grade MALT lymphoma to H pylori eradication.
A retrospective, single-center study.
Twenty-two patients with primary gastric MALT lymphoma were identified through a retrospective review of charts of patients seen at the American University of Beirut Medical Center. Only 19 patients with histopathologically confirmed gastric MALT lymphoma and H pylori infection who had EUS staging were included in the study.
Regression of the gastric MALT lymphoma as determined by follow-up endoscopy and mucosal biopsies.
Patients with disease restricted to the gastric mucosa had a significantly higher rate of complete remission after H pylori eradication compared with patients who had disease infiltrating into the gastric submucosa (77.8% vs 12.5%, P value .007). There was no statistical difference in terms of the mean follow-up time to achieve such response (P value .212). Age, sex, location of the tumor within the stomach, and endoscopic appearance did not correlate with the probability of complete remission of the MALT lymphoma.
The limitations include a retrospective design and a relatively small sample population.
EUS determination of the invasion depth of gastric MALT lymphoma helps predict a complete response to H pylori eradication.
胃黏膜相关淋巴组织（MALT）淋巴瘤与幽门螺杆菌感染相关，根除幽门螺杆菌后肿瘤可消退。
除其他临床/内镜特征外，确定超声内镜（EUS）在预测低度MALT淋巴瘤对幽门螺杆菌根除治疗反应中的价值。
一项回顾性单中心研究。
通过回顾性查阅贝鲁特美国大学医学中心就诊患者的病历，确定了22例原发性胃MALT淋巴瘤患者。本研究仅纳入19例经组织病理学确诊为胃MALT淋巴瘤且感染幽门螺杆菌并接受EUS分期的患者。
通过随访内镜检查和黏膜活检确定胃MALT淋巴瘤的消退情况。
与病变浸润至胃黏膜下层的患者相比，病变局限于胃黏膜的患者在根除幽门螺杆菌后完全缓解率显著更高（77.8%对12.5%，P值为0.007）。达到这种反应的平均随访时间无统计学差异（P值为0.212）。年龄、性别、肿瘤在胃内的位置以及内镜表现与MALT淋巴瘤完全缓解的可能性无关。
局限性包括回顾性设计和相对较小的样本量。
EUS确定胃MALT淋巴瘤的浸润深度有助于预测对幽门螺杆菌根除治疗的完全反应。
