Shen Qian-Hua, Saijo Yusuke, Mauch Stefan, Biskup Christoph, Bieri Stéphane, Keller Beat, Seki Hikaru, Ulker Bekir, Somssich Imre E, Schulze-Lefert Paul
Department of Plant Microbe Interactions, Max-Planck-Institut für Züchtungsforschung, Carl-von-Linné-Weg 10, D-50829 Köln, Germany.
Science. 2007 Feb 23;315(5815):1098-103. doi: 10.1126/science.1136372. Epub 2006 Dec 21.
Plant immune responses are triggered by pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs) or by resistance (R) proteins recognizing isolate-specific pathogen effectors. We show that in barley, intracellular mildew A (MLA) R proteins function in the nucleus to confer resistance against the powdery mildew fungus. Recognition of the fungal avirulence A10 effector by MLA10 induces nuclear associations between receptor and WRKY transcription factors. The identified WRKY proteins act as repressors of PAMP-triggered basal defense. MLA appears to interfere with the WRKY repressor function, thereby de-repressing PAMP-triggered basal defense. Our findings reveal a mechanism by which these polymorphic immune receptors integrate distinct pathogen signals.
植物免疫反应由检测保守病原体相关分子模式（PAMPs）的模式识别受体触发，或由识别特定分离病原体效应子的抗性（R）蛋白触发。我们发现，在大麦中，细胞内抗白粉病A（MLA）R蛋白在细胞核中发挥作用，赋予对白粉病真菌的抗性。MLA10对真菌无毒力A10效应子的识别诱导了受体与WRKY转录因子之间的核关联。已鉴定的WRKY蛋白作为PAMP触发的基础防御的抑制因子。MLA似乎干扰了WRKY抑制因子的功能，从而解除了对PAMP触发的基础防御的抑制。我们的研究结果揭示了这些多态性免疫受体整合不同病原体信号的机制。
