产后精神疾病：一项关于一般健康问卷-12（GHQ-12）和爱丁堡产后抑郁量表（EPDS）作为筛查工具的效度研究
Postnatal psychiatric morbidity: a validation study of the GHQ-12 and the EPDS as screening tools.
作者信息
Navarro Purificación, Ascaso Carlos, Garcia-Esteve Lluïsa, Aguado Jaume, Torres Anna, Martín-Santos Rocío
机构信息
Unit of Perinatal Psychiatry and Gender Research, Hospital Clínic Universitari de Barcelona, 08028 Barcelona, Spain.
出版信息
Gen Hosp Psychiatry. 2007 Jan-Feb;29(1):1-7. doi: 10.1016/j.genhosppsych.2006.10.004.
OBJECTIVE
To assess the validity of the 12-Item General Health Questionnaire (GHQ-12) and the Edinburgh Postnatal Depression Scale (EPDS) in screening for the most common postnatal psychiatric morbidities (mood, anxiety and adjustment disorders).
METHOD
A two-phase cross-sectional study was designed. First, a sample of 1453 women visiting at 6 weeks postpartum completed the GHQ-12 and the EPDS questionnaires. Second, based upon EPDS outcomes, participants were stratified and randomly selected within each stratum for clinical evaluation [Structured Clinical Interview for DSM-IV (SCID)]. Receiver operating characteristic (ROC) analysis was used.
RESULTS
The concurrent validity was satisfactory (0.80). At optimum cut-off scores, both GHQ-12 and EPDS yielded very good sensitivity (80; 85.5) and specificity (80.4; 85.3), respectively. ROC curves showed that the performance of the EPDS (AUC=0.933) is slightly superior to that of GHQ-12 (AUC=0.904).
CONCLUSION
Both GHQ-12 and EPDS are valid instruments to detect postnatal depression as well as postnatal anxiety and adjustment disorders.
目的
评估12项一般健康问卷（GHQ - 12）和爱丁堡产后抑郁量表（EPDS）在筛查最常见的产后精神疾病（情绪、焦虑和适应障碍）方面的有效性。
方法
设计了一项两阶段横断面研究。首先，1453名产后6周就诊的女性样本完成了GHQ - 12和EPDS问卷。其次，根据EPDS结果，对参与者进行分层，并在各层内随机选择进行临床评估[DSM - IV结构化临床访谈（SCID）]。采用受试者工作特征（ROC）分析。
结果
同时效度令人满意（0.80）。在最佳截断分数时，GHQ - 12和EPDS的敏感性分别非常好（80；85.5）和特异性（80.4；85.3）。ROC曲线显示，EPDS的表现（AUC = 0.933）略优于GHQ - 12（AUC = 0.904）。
结论
GHQ - 12和EPDS都是检测产后抑郁以及产后焦虑和适应障碍的有效工具。
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