Holm A C, Lemarchand-Béraud T, Scazziga B R, Cuttelod S
Acta Endocrinol (Copenh). 1975 Dec;80(4):642-56. doi: 10.1530/acta.0.0800642.
The human lymphocyte has been investigated regarding its function as a thyroid hormone target cell. Binding and deiodination of the thyroid hormones were determined after simultaneous incubation of 131I-labelled L-thyroxine (131I-T4) and 125I-labelled L-triiodothyronine (125I-T3) with lymphocytes from healthy subjects, from hyperthyroid and primary hypothyroid patients before and after treatment. The mean percentages of binding, 8.0 +/- 0.5 (mean +/- SEM) for 131I-T4, and 9.7 +/- 0.4 for 125I-T3 in the control group, were increased in the hyperthyroids to 10.1 +/- 0.4 and 12.7 +/- 0.6 respectively, and in the hypothyroids to 10.9 +/- 0.7 and 12.8 +/- 0.6. All elevated values returned to normal with successful treatment. The mean percentage of deiodination, 12.0 +/- 1.7 for 131I-T4, and 6.5 +/- 0.9 for 125I-T3 in the control group, showed a threefold increase in the hyperthyroid patients, to 35.9 +/- 3.2 and 20.2 +/- 1.9 respectively and remained unaltered in the hypothyroid patients. The values of successfully treated hyperthyroid patients were normal and those of the treated hypothyroid patients below normal.
对人类淋巴细胞作为甲状腺激素靶细胞的功能进行了研究。在将¹³¹I标记的L-甲状腺素（¹³¹I-T4）和¹²⁵I标记的L-三碘甲状腺原氨酸（¹²⁵I-T3）与健康受试者、甲状腺功能亢进和原发性甲状腺功能减退患者治疗前后的淋巴细胞同时孵育后，测定甲状腺激素的结合和脱碘情况。对照组中¹³¹I-T4的平均结合百分比为8.0±0.5（平均值±标准误），¹²⁵I-T3为9.7±0.4，甲状腺功能亢进患者中分别增加到10.1±0.4和12.7±0.6，甲状腺功能减退患者中增加到10.9±0.7和12.8±0.6。成功治疗后，所有升高的值均恢复正常。对照组中¹³¹I-T4的平均脱碘百分比为12.0±1.7，¹²⁵I-T3为6.5±0.9，甲状腺功能亢进患者中增加了两倍，分别为35.9±3.2和20.2±1.9，甲状腺功能减退患者中保持不变。成功治疗的甲状腺功能亢进患者的值正常，治疗的甲状腺功能减退患者的值低于正常。
