[人类年龄与人类血细胞中线粒体DNA 4977缺失之间的关系]
[Relationship between human age and mtDNA 4977 deletions in human blood cells].
作者信息
Li Cheng-Tao, Li Li, Liu Yan
机构信息
Institute of Forensic Sciences, Ministry of Justice, P. R. China, Shanghai 200063, China.
出版信息
Fa Yi Xue Za Zhi. 2006 Oct 15;22(5):346-8.
OBJECTIVE
To study the relationship between human age and mtDNA 4977 deletions in human blood cells.
METHODS
According to Anderson's sequence, two sets of primers were designed. Human mtDNA 4977 deletions in blood samples from 110 healthy human individuals in different age groups were examined by using Real time quantitative PCR.
RESULTS
The mtDNA 4977 deletions could be observed unless the age was under 23 years old. The older the people were, the easier the deletion could be observed.
CONCLUSION
mtDNA 4977 deletions in human blood cells were correlated with human ages in some extent.
目的
研究人类年龄与人类血细胞中线粒体DNA 4977缺失之间的关系。
方法
根据安德森序列设计两组引物。采用实时定量PCR检测110名不同年龄组健康人类个体血样中的人类线粒体DNA 4977缺失情况。
结果
除非年龄在23岁以下，否则均可观察到线粒体DNA 4977缺失。年龄越大，越容易观察到缺失。
结论
人类血细胞中线粒体DNA 4977缺失在一定程度上与人类年龄相关。
Zotero 插件